منابع مشابه
Neurotransmitter receptors on microglia
As the resident immune cells in the central nervous system, microglia have long been hypothesised to promote neuroinflammation and exacerbate neurotoxicity. However, this traditional view has undergone recent revision as evidence has accumulated that microglia exert beneficial and detrimental effects depending on activation status, polarisation phenotype and cellular context. A variety of neuro...
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Microglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile processes. Microglia are closely associated with astrocytes and neurons, particularly at the synapses, and more recent data indicate that neurotransmission plays a role in regulating the morphology...
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Since the discovery of the major excitatory and inhibitory neurotransmitters and their receptors in the brain, many have deliberated over their likely structures and how these may relate to function. This was initially satisfied by the determination of the first amino acid sequences of the Cys-loop receptors that recognized acetylcholine, serotonin, GABA, and glycine, followed later by similar ...
متن کاملErratum: Neurotransmitter signaling in the pathophysiology of microglia
At the top of page 5, the following changes need to be made. . . . regulators of P2X4R expression in microglia have been described, such as the chemokine CCL2 (also known as monocyte chemoattractant protein, MCP-1; Biber et al., 2011; Toyomitsu et al., 2012),. . .. Leaving the corrected text as follows: . . . regulators of P2X4R expression in microglia have been described, such as the chemokine...
متن کاملNeurotransmitter Receptors in the Postsynaptic Neuron
Communication between adjacent neurons in the central nervous system occurs at specialized regions of the nerve cells termed the synapse. It is mediated by themovement of chemical mediators or neurotransmitters across a small gap that exists between the nerve cells. When a neuron is activated, it releases molecules of neurotransmitter from synaptic vesicles localized in the presynaptic terminal...
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ژورنال
عنوان ژورنال: BMJ
سال: 2016
ISSN: 2059-8688,2059-8696
DOI: 10.1136/svn-2016-000012